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ecg signals  (MedChemExpress)
94
MedChemExpress ecg signals
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ecg Signals, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ground truth ecg signals  (PLUX Biosignals SA)
93
PLUX Biosignals SA ground truth ecg signals
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ground Truth Ecg Signals, supplied by PLUX Biosignals SA, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ecg signals  (BioSignal Group)
90
BioSignal Group ecg signals
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ecg Signals, supplied by BioSignal Group, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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time- frequency representations of ecg signals generated in matlab r2020 b  (MathWorks Inc)
90
MathWorks Inc time- frequency representations of ecg signals generated in matlab r2020 b
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Time Frequency Representations Of Ecg Signals Generated In Matlab R2020 B, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ecg signals  (MindWare Technologies LTD)
90
MindWare Technologies LTD ecg signals
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ecg Signals, supplied by MindWare Technologies LTD, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ecg signal preprocessing  (MathWorks Inc)
98
MathWorks Inc ecg signal preprocessing
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ecg Signal Preprocessing, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ecg signal  (ZOLL Medical)
90
ZOLL Medical ecg signal
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ecg Signal, supplied by ZOLL Medical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ecg signal amplifier  (ADInstruments)
90
ADInstruments ecg signal amplifier
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Ecg Signal Amplifier, supplied by ADInstruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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device for capturing and transmitting the ecg signal  (Consis Medical Ltd)
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Consis Medical Ltd device for capturing and transmitting the ecg signal
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
Device For Capturing And Transmitting The Ecg Signal, supplied by Consis Medical Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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ecg signals  (brain products gmbh)
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brain products gmbh ecg signals
a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface <t>electrocardiograms</t> recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.
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Image Search Results


a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface electrocardiograms recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.

Journal: Nature Communications

Article Title: Platelet-bioengineered hiPSC-sEVs achieve targeted repair of fibrotic sinoatrial node in preclinical SND models

doi: 10.1038/s41467-025-65936-0

Figure Lengend Snippet: a Key features of the SH-IR SND model. Created in BioRender. Liu, J. (2025) https://BioRender.com/d69k920 ; b Schematic of the SH-IR model construction (yellow outline - SAN area; SVC: superior vena cava; RAA: right atrial appendage; Ao: aorta); c Comparison of heart rate and R-R interval length before and after modeling ( n = 15 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (**** P < 0.0001); d Surface electrocardiograms recorded post-modeling reveal hallmark arrhythmias of SND; e Analysis of heart rate variability before and after modeling, including time-domain parameters (e.g., AVNN), nonlinear Poincaré plot metrics (SD1, SD2, and SD1/SD2), DFA long-term fluctuation index (α2), and sample entropy (SampEn) ( n = 16 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (* P < 0.05, *** P < 0.001, **** P < 0.0001); f Representative electrocardiograms from treatment groups before modeling, after modeling, and 28 days post-treatment; g Longitudinal measurements of heart rate, R-R interval, and relative heart rate reduction ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05, *** P < 0.001; ns, not significant); h ADSNRT was assessed in the PM@i-sEV group after modeling and at 28 days post-treatment ( n = 3 biological independent rats). Statistical significance was determined by a paired, two-tailed t -test (** P < 0.01); i Intrinsic heart rate measurements after autonomic nervous system blockade were performed. Red arrows denote normal sinus P waves, while gray arrows indicate inverted P’ waves originating from ectopic non-SAN pacemaker sites. Statistical analysis of intrinsic frequency was conducted on day 28 ( n = 5 biological independent rats per group). Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (* P < 0.05; ns, not significant). Results were presented as mean ± SEM. Source data are provided as a Source Data file.

Article Snippet: After obtaining stable ECG signals from the rats, adenosine (1 mg/kg, HY-B0228, MCE) was rapidly injected via the tail vein.

Techniques: Comparison, Two Tailed Test